Mineh Onomake, age 14, was last seen on Cardrona Street, Gorton at around 3.45pm on Sunday 23 May.
She is described as being black, 5ft 8ins tall and of a medium build with black shoulder length hair.
Mineh was last seen wearing a red puffer jacket with a black hood, a black hoody with white writing on the chest, black jogging bottoms and black and white Jordan 11 trainers.
Superintendent Helen Critchley, of GMP’s City of Manchester division, said: “We are all extremely worried about Mineh’s wellbeing. She is a young girl who very rarely misses school and has not been seen for three days.
“Mineh if you are reading this please know you are not in trouble, your family love you and just want you home safely.
“I urge anyone with any information about Mineh’s current whereabouts or her movements since Sunday to contact police immediately so we can reunite this family.”
Officers are becoming increasingly concerned about Mineh and want to make sure she is safe and well.
Anyone with information about Mineh’s whereabouts should contact police on 0161 856 1884.
