Isabella Skelton nee McDowall – also known as Izzy – went missing in June 1969 aged 35.
At the time she was living on Lidiard Street, Crumpsall.
Isabella would be aged 86 today, having been born in Glasgow on 21 January 1934.
Married to Lewis Skelton in July 1952 she was the mother of three children – Linda, Richard and Stephen.
She moved to Manchester in the early 1960s, first living in Salford then moving to Crumpsall.
It is believed she attended school in Anderson Cross, Scotland and at the time had a good friend called Anna Owen.
She did some work in a florist and also worked for the James Howden engineering company in Glasgow.
When in Manchester Isabella previously worked at Atlas Express in Blackfriars, Salford. She is also believed to have worked at Gallagher Cigarettes and Ball Bearings Services, the latter at the time of her disappearance.
Her family grew up under the belief that she had left Manchester to work away for a period.
However, her family never saw Isabella again.
Detective Inspector Claire Moss of GMP’s City of Manchester Division said: “After more than 50 years, Isabella’s family are still desperately looking for answers.
“There is no record of Isabella after she left Manchester and there is no record of her death.
“We therefore believe she is still alive and remains classed as a missing person with GMP.
“We appreciate that we are talking about a long timeframe, with little information to go on, but we hope that someone may recognise the image we’re releasing today.
“We owe it to Isabella’s family not to stop looking for her.”
Anyone with information should call police on 101 or the independent charity Crimestoppers, anonymously, on 0800 555 111.